Effect of ligustrazine pretreatment on electroretinogram of rats after retinal ischemic-reperfusion injury

Objective:To observe the effect of ligustrazine pretreatment on ERG of rats after retinal ischemic-reperfusion injury.Methods: Experimental retinal ischemic-reperfusion injury was induced by increasing the intraocular pressure through infusion of the right anterior chamber.Full-filled ERGs were recorded simultaneously from treated and control eyes before and 30 min following ischemia,lh,12h,24h,72h and 168h following reperfusion.Meanwhile,the recovery rate of b and O2 waves were calculated(Recovery rate =treated/control×100%).Results: No evident waves were detected during retina ischemia and waves of b and O2 were significantly decreased after reperfusion compared with the normal group.Ligustrazine pretreatment can obviously promote the recovery of both waves(P 0.05).Conclusions:Ligustrazine pretreatment can obviously promote the recovery of retinal function following ischemia-reperfusion injury in rats.