Study of platelet membrane glycoproteins and parameters of platelet in acute cerebral infarction

Objective: To investigate the association of the function of platelet with acute cerebral infarction(ACI) and estimate accurately the function of platelet.Methods: A study of 51 hospitalized cases with ACI was conducted,and 29 cases of healthy subjects were randomly selected as controls.The positive percentages of activated platelet membrane glycoprotein GPⅡb/Ⅲa complex monoclonal antibody(PAC-1),platelet α-granular membrane protein,P-selectin monoclonal antibody(CD62P) were detected with flow cytometer(FCM) in all patients.Parameters of platelet were measured by using automatic blood analyzer in all patients.Results: Comparing the data with the clinical controls,the positive percentages of PAC1,CD62P and mean platelet volume(MPV) were significantly higher in the patients of ACI group(P0.05 or P0.01).There were no differences between the two groups in platelet count(PC),platelet distribution width(PDW) and large platelet rate(LPR)(all P0.05).PAC-1 was positively correlated with MPV(r=0.322,P=0.004) and LPR(r=0.224,P=0.046),respectively.CD62P was positively correlated with MPV similarly(r=0.240,P=0.032).On the other hand neither PC nor PDW had any correlation with platelet membrane glycoprotein(P0.05).Conclusion: In cases with ACI,the platelet activation,platelet membrane glycoprotein and various platelet parameters all together play a role in the pathological processes.Activated GPⅡb/Ⅲa is markedly correlated positively with MPV.The detection of platelet membrane glycoprotein and platelet parameters can estimate accurately the function of platelet.