Relationship between urinary albumin excretion rate and high-sensitive C-reactive protein in elderly patients with type 2 diabetes

Objective To investigate the relationship between urinary albumin excretion rate(UAER)and high-sensitive C-reactive protein(hs-CRP)in elderly patients with type 2 diabetes.Methods Two hundred and ten patients with type 2 diabetes were divided into 3 groups according to UAER:nomral albuminuria(NAU), microalbuminuria(MAU)and clinical albuminuria(CAU);100 healthy subjects were taken as controls.The plasma level of hs-CRP were determined in all patients and the relationship between UAER and other relevant factors was analyzed with linear correlation method.Results The hs-CRP levels in the NAU group,MAU group and CAU group were(1.5±0.2) mg/L,(3.0±0.9) mg/L and (4.4±1.9) mg/L,respectively;all significantly higher than that of the control group([0.2±0.1]mg/L,P0.01).The hs-CRP levels in the MAU group and CAU group were significantly higher than that in NAU group(P0.01).Linear correlation showed that UAER level in diabetes patients was positively related to HOMA-IR(P0.01),hs-CRP(P0.01)and HbA_1c(P0.05). Conclusion Increased hs-CRP level is correlated with the morbidities of type 2 diabetes and diabetic nephropathy (DN),suggesting that hs-CRP play an important role in prediction of DN.(Shanghai Med J,2007,30:834-836)