Atorvastatin Combined with Ezetimibe in the Treatment of Patients with Hypercholesterolemia

Objective:To investigate the efficacy of atorvastatin combined with ezetimibe in the treatment of patients with hypercholesterolemia.Methods:Forty patients(23 males,17 females,aged 58±12 yrs)with severe hypercholesterolemia who failed to achieve lipid lowering target level(LDL-C2.6 mmol/L)after 6 months treatment with atorvastatin(20mg,Qd)were added with ezetimibe(10 mg,Qd)for 3 months observation.Results:After 6 months treatment with atorvastatin,the lipids of TC,LDL-C,TG,ApoB and Lp(a)were decreased and HDL-C elevated remarkably than those at baseline,and with P0.01 respectively.When combined with ezetimibe for 3 months,the lipid level of TC,LDL-C and ApoB was reduced than that of merely using atorvastatin,and with P0.01 in respect.No significant abnormalities were found in particular with AST,ALT and CK during this therapy.Conclusion:Atorvastatin combined with ezetimibe can produce further lipid lowering effects than only atorvastatin in patient with severe hypercholesterolemia.