Urine and hair levels of fluorine and aluminum and bone histomorphometry in endemic osteomalacia children in Guizhou province

Objective To determine urine and hair levels of fluorine and aluminum and bone histomorphometry in endemic osteomalacia children in Guizhou province.Methods Urine and hair levels of fluorine,aluminum and so on were detected in 14 osteomalacia and 7 normal children,and bone histomorphometry of the anterior superior iliac spine was done in 2 osteomalacia and 2 normal children.Results Urine fluorine,and urine and hair aluminum contents in patients were 2.46,2.39 and 3.17 times respectively compared with controls(P0.05).The bone histomorphometry of osteomalacia children showed the derangement of trabecular collagen fibers,chondrocytes within bone,massive osteoids around trabeculae,increased osteoid perimeter and area,and elevated lacunar resorption.Conclusion The children with endemic osteomalacia in Guizhou present with fluorine and aluminum poisoning,and the characteristics of bone histomorphometry are disordered bone mineralization and increased resorption.