Expression of P450 aromatase in endometrial carcinoma

Objective To investigate the funcion of P450 aromatase in normal,hyperplasia en- dometrium and endometrioid endometrial carcinoma.Methods There were three experimental groups:en- dometrial carcinoma(50 cases),endometrial hyperplasia(27 cases),and normal endometrium(20 cases). P450arom was detected by using immunohistochemical methods(ABC method)with specific antibodies.Re- stilts P450aroma was expressed in the glandular epithelial of hyperplasia and malignant endometrium,there was no difference between two groups(P0.05).Immunohistochemical staining for intratumoral aromatase in endometrial cancer was positive,21(42 %)in stromal cells.The expression of P450 aromatase in stromal cells correlated positively with advanced surgical stage and histologic grade,indepedent on muscular invasion and lymph node metastasis.Conclusion Aromatase P450 play an important function in establishment and devel- opment of the endometrioid endometrial cancer.The expression of P450 aromatase in intratumoral stromal cells correlated positively with the development and prognosis of endometrioid endometrial cancer.