Clinical Significance and Measurment of Interferon-γand Interleukin-4 Levels in Complete Remission Acute Leukemia Patients

Objective: To study the change of immune function in the complete remission acute Leakemia patients and explore the relationship between levels of IFN-γ and IL-4 and prognosis of patients,and provide the theorerical foundation for the clinical chemotherapy. Methods: Levels of IFN-γ was measured by ELISA.and levels of IL-4 was measured by immunological method Results- In general, the levels of IFN-γ and IL-4 recovered to normal levels in CR patients, The levels of serum IFN-γ in first visit patients and CR short stage group,CR middle stage group and CR long stage group of acute leukemia patients increased successively,but IL-4 decreased successively. In complete remission IFN-γhad negative correlation with IL-4. Conclusion:In complete remission of acute leukemia patients, Along with time extent in CR.the immunological function recoved gradually. Therefore we could estimate immunity state and pragnosis by testing the level of serunm IFN-γand IL-4 in CR acute leukemia patients, and provide important theropy. If corrected liquid and the loss balance of immunological function sooner, this may provide new chemotherapy way to shorten the recurring of acute leukemia.