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The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa

Xiaoling Wu

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Abstract

Objective: To investigate the expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. Methods: SP immunohistochemistry. Results: The expression rate of Fas in chronic superficial gastritis group was significantly higher than that of dysplasia and gastric cancer groups (P0.05). The expression rate of Fas ligand in chronic superficial gastritis group was significantly lower than that of other groups ( P0.05). In the patients with gastric cancer, the expression rates of Fas and Fas ligand were correlated with the degree of differentiation. Conclusion: The abnormal expression of Fas and Fas ligand in carcinogenesis of gastric mucosa may be involved in the pathogenesis and differentiation of gastric cancer.

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What this paper is about

Objective: To investigate the expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. Methods: SP immunohistochemistry. Results: The expression rate of Fas in chronic superficial gastritis group was significantly higher than that of dysplasia and gastric cancer groups (P0.05). The expression rate of Fas ligand in chronic superficial gastritis group was significantly lower than that of other groups ( P0.05). In the patients with gastric cancer, the expression rates of Fas and Fas ligand were correlated with the degree of differentiation. Conclusion: The abnormal expression of Fas and Fas ligand in carcinogenesis of gastric mucosa may be involved in the pathogenesis and differentiation of gastric cancer.

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Available abstract

Objective: To investigate the expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. Methods: SP immunohistochemistry. Results: The expression rate of Fas in chronic superficial gastritis group was significantly higher than that of dysplasia and gastric cancer groups (P0.05). The expression rate of Fas ligand in chronic superficial gastritis group was significantly lower than that of other groups ( P0.05). In the patients with gastric cancer, the expression rates of Fas and Fas ligand were correlated with the degree of differentiation. Conclusion: The abnormal expression of Fas and Fas ligand in carcinogenesis of gastric mucosa may be involved in the pathogenesis and differentiation of gastric cancer.

Key concepts: Carcinogenesis, Fas ligand, Immunohistochemistry, Cancer, Pathogenesis, Gastric mucosa, Dysplasia, Medicine

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