Analysis and Clinical Significance of Cancer Patients' Serum Cholesterol Level and Telomerase Activity

Objective To research into serum cholesterol level and telomerase activity and their clinical significance in patients with cancer.Methods The cholesterol levels of 130 cases of untreated cancer patients,94 no cancer patients and 100 healthy subjects were examined respectively.The total cholesterol levels before and after the rectifications of low protein in 77 cases of cancer patients with hypoproteinemia were analyzed.In addition,to detect telomerase activity in same 130 cancer patients of different cancer tissues and tumor adjacent tissues and 35 cases of corresponding normal epithelial tissues by PCR-ELISA.Results The serum cholesterol level of carcinoma group was significantly lower than that in the no carcinoma group(P0.01).and there was no difference between the non carcinoma group and the healthy group(P0.05).After the rectification,the cholesterol level was increased significantly and approached that of healthy group.Positive rate of different cancer tissues' telomerase activity was:the stomach cancer tissues 81.8%(9/11),the liver cancer tissues 83.2%(10/12),the lung cancer tissues 87.5%(21/24),the esophagus carcinoma tissues 85.7%(6/7),the breast cancer tissues 75%(6/8),the prostate cancer tissues 84.6%(11/13)and so on;Positive rate of different tumor tissues'telomerase activity was not obvious difference(P0.05).Positive rate of tumor adjacent tissues' telomerase activity was:the stomach cancer adjacent tissues 9.09%(1/11),the liver cancer adjacent tissues 8.33%(1/12),the lung cancer adjacent tissues 12.5%(3/24),the esophagus carcinoma adjacent tissues 14.3%(1/7),the breast cancer adjacent tissues 12.5%(1/8),the prostate cancer adjacent tissues 15.4%(2/13) and so on.Comparing with cancer tissues,they have notable difference(P0.01).Conclusion During the pathogenesis of tumor,the reproductions of tumor cells were accelerated and uncontrollable.In order to meet the need of synthesizing the tumor cell membrane,and simultaneously increases the LDL metabolism,the effect of which causes cells to ingest a great amount of cholesterol from blood LDL granule,the cholesterol content decreased.After the rectifications of protein,the cholesterol levels of cancer patients enhanced distinctly and prompted hypocholesteremia by no means for the endogenetic cancer factors.Positive rate of different cancer tissues'telomerase activity was high,but telomerase activity's positive rate of normal tissues and its tumor adjacent tissues were none or extremely low.Hence the cholesterol level is a useful criterion in assisting tumor diagnosis and monitoring prognosis.The examination of telomerase to the malignant cancer diagnosis and the finding of pathological change had the vital clinical significance.