Maximum Non-Effect Dose of Profurite-Aminium

[Objective] To study the sub-chronic toxicity of profurite-aminium on rats and obtain its maximum non-effect dose.[Methods] Experiments were carried out according to the GB 15670-1995 Toxicological Test Methods for Pesticides Registration Three dose groups(low dose level of 7.5mg/kg,intermediate dose level of 30mg/kg,high dose level of 120mg/kg) and a control group were established.The test parameters included blood,urine,blood biochemistry and pathological examination.Body weights and food consumption were recorded weekly.Organs were surgically removed and recorded at term.Then the data were dealt with statistics analysis.[Results] ALP in intermediate dose group was lower than the control group,while weight of liver and kidney,the ratio of liver to body and the ratio of kidney to body in intermediate dose group were higher than the control group;In high dose group,ALP was lower than the control group,heart weight was higher than the control group,the ratio of heart to body,kidney to body and liver to body of female rats were higher than the control group,weight of brain,liver,spleen,kidney and heart,the ratio of spleen to body and liver to body of male rats were higher than the control group.The pathological examination indicated that in intermediate and high dose group the rate of pathological changes of liver and lung was higher.[Conclusion]The maximum non-effect dose of the profurife-aminium were(0.62±0.03) mg/(kg.d) for female rats and(0.56±0.03) mg/(kg.d) for male rats