Expression of TARC and Eotaxin-2 in allergic rhinitis and its clinical significance

OBJECTIVE To determine the level of chemotatic factor Eotaxin-2 and thymus and activation regulated chemokine(TARC)in serum of patients with allergic rhinitis(AR),and discuss their role and clinical significance.METHODS ELISA was applied to assay the chemokines of TARC and Eotaxin-2.RESULTS ① High level of TARC and Eotaxin-2 was detected in the AR patients,which was significantly different from that of NAR.②TARC and Eotaxin-2 in the mild and moderatesevere persistent AR patients significantly increased,compared with NAR,as determined by Student's t test.The TARC OD results were 0.475±0.035,0.475±0.015,0.425±0.030 separately(t =2.100,P =0.011;t =3.080,P =0.010);the Eotaxin-2 OD results were 2.660± 0.900,3.13±1.375,1.055±0.33(t =6.874,P =0.032;t=5.900,P=0.034),in both of which the listed turn was mild persistent AR,moderate-severe persistent AR and NAR.③TARC showed positive correlation with Eotaxin-2 by linear correlation analysis(r =0.880,P 0.01).CONCLUSION The increased expression of TARC and Eotaxin-2 in AR was well evidenced.TARC showed positive correlation with Eotaxin-2.This result may be due to Th2 cell response,which could directly lead to morbidity.Yet,the expression level of TARC and Eotaxin-2 had no relation to varying severity of allergic symptoms.