Clinical study on detection of drug resistance genes in the treatment of patients with pulmonary tuberculosis

Objective To investigate the application of gene chip in the detection of antimicrobial resistance in patients with pulmonary tuberculosis. Methods There were 83 patients with relapse bacillary pulmonary tuberculosis. On the basis of antibiotic sensitivity test results,56 multi-drug resistant pulmonary tuberculosis patients were randomly divided into two groups. The gene chip group( n = 24) was given individualized anti-tuberculosis chemotherapy based on gene chip detection results,and the observation group was given anti-tuberculosis chemotherapy based on conventional drug susceptibility. The rate of lesions absorbed and sputum bacteria negative-transformation was observed. Results The sputum bacteria negative transformation rate was 58. 3% in the gene chip group,which was slightly higher than 53. 2% in the observation group. 45. 9% had lesions absorbed in the gene chip group,which was slightly higher than 43. 8% in the observation group. Conclusion Gene chip technology is fast and accurate,which can be used for tuberculosis drug resistance detection.