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Relation Between Expression of COX-2 and Survivin in NPC and Their Clinical Significance

Zhou Le-yuan

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Abstract

Objective To study the expression of COX-2 in nasopharyngeal carcinoma(NPC) tissue and its relation with expression of Survivin.Methods The expression of COX-2 and Survivin was assessed by immunohistochemistry staining in 43 NPC tissues.Results In the NPC tissues,the positivity rate of COX-2 and Survivin expression was 79.1%(33/43),76.7%(32/43).The expression of COX-2 was significantly higher in phase Ⅳ than that in the other phases.There also was a strong positive correlation between COX-2 and Survivin(P0.01).Conclusion The high expression of COX-2 may play an important role in NPC,probably by means of inhibiting the tumor cells apoptosis.

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What this paper is about

Objective To study the expression of COX-2 in nasopharyngeal carcinoma(NPC) tissue and its relation with expression of Survivin.Methods The expression of COX-2 and Survivin was assessed by immunohistochemistry staining in 43 NPC tissues.Results In the NPC tissues,the positivity rate of COX-2 and Survivin expression was 79.1%(33/43),76.7%(32/43).The expression of COX-2 was significantly higher in phase Ⅳ than that in the other phases.There also was a strong positive correlation between COX-2 and Survivin(P0.01).Conclusion The high expression of COX-2 may play an important role in NPC,probably by means of inhibiting the tumor cells apoptosis.

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Available abstract

Objective To study the expression of COX-2 in nasopharyngeal carcinoma(NPC) tissue and its relation with expression of Survivin.Methods The expression of COX-2 and Survivin was assessed by immunohistochemistry staining in 43 NPC tissues.Results In the NPC tissues,the positivity rate of COX-2 and Survivin expression was 79.1%(33/43),76.7%(32/43).The expression of COX-2 was significantly higher in phase Ⅳ than that in the other phases.There also was a strong positive correlation between COX-2 and Survivin(P0.01).Conclusion The high expression of COX-2 may play an important role in NPC,probably by means of inhibiting the tumor cells apoptosis.

Key concepts: Survivin, Nasopharyngeal carcinoma, Immunohistochemistry, Medicine, Cancer research, Apoptosis, Clinical significance, Pathology

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