2011•Linchuang gandanbing zazhiRequires access
Central pontine and extrapontine myelinolysis following liver transplantation
YU Li-xin
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Abstract
Objective To investigate the pathogenesis,clinical characteristics and prognosis of central pontine and extrapontine myelinolysis following liver transplantation.Methods 8 cases diagnosed as central pontine and extrapontine myelinolysis following liver transplantation were retrospectively analyzed.Results Aphasia,dysphagia,epilepsy and coma were observed in early period of post liver transplantation.Among the 8 cases,2 cases were restored to consciousness with mental disorder,4 cases were still in coma until discharged,and 2 cases died of MODS.Conclusion The main pathogenesis of central pontine and extrapontine myelinolysis following liver transplantation is severe change of plasma osmotic pressure with diversity of clinical characteristics and poor prognosis.Combination treatment with plasmapheresis and intravenous immunoglobulin may improve neurologic outcome.