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1991•Chinese Journal of PharmaceuticalsRequires access

PHARMACOKINETICS OF CARBOPLATIN AND CISPLATIN IN RATS

Wen Li

Open publisher page 3 citations

Abstract

The pharmacokinetics of carboplatin(1)and cisplatin(2)wasobserved in Spraque-Dawly rats.The serum concentration-time curves were biphasicin the period studied(0～24h),with T_(1/2β) of 14～16h for 1 and 23h for 2,90%of platinum administered was excreted in 24h urine for 1,and about 39% for 2.The mean AUC value for 30mg/kg 1 was 35μg/ml·h,for 10mg/kg 2 was 36μg/ml·h.The distribution of Pt in tissues showed that kidney had the highest concentration.The results accorded with the less nephrotoxicity of 1 in comparison with 2.

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What this paper is about

The pharmacokinetics of carboplatin(1)and cisplatin(2)wasobserved in Spraque-Dawly rats.The serum concentration-time curves were biphasicin the period studied(0～24h),with T_(1/2β) of 14～16h for 1 and 23h for 2,90%of platinum administered was excreted in 24h urine for 1,and about 39% for 2.The mean AUC value for 30mg/kg 1 was 35μg/ml·h,for 10mg/kg 2 was 36μg/ml·h.The distribution of Pt in tissues showed that kidney had the highest concentration.The results accorded with the less nephrotoxicity of 1 in comparison with 2.

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Available abstract

The pharmacokinetics of carboplatin(1)and cisplatin(2)wasobserved in Spraque-Dawly rats.The serum concentration-time curves were biphasicin the period studied(0～24h),with T_(1/2β) of 14～16h for 1 and 23h for 2,90%of platinum administered was excreted in 24h urine for 1,and about 39% for 2.The mean AUC value for 30mg/kg 1 was 35μg/ml·h,for 10mg/kg 2 was 36μg/ml·h.The distribution of Pt in tissues showed that kidney had the highest concentration.The results accorded with the less nephrotoxicity of 1 in comparison with 2.

Key concepts: Carboplatin, Pharmacokinetics, Chemistry, Cisplatin, Nephrotoxicity, Urine, Pharmacology, Kidney

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