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2008•Acta Academiae Medicinae WeifangRequires access

Study on the Expression of PCNA and Bcl-2 in Patients with Chronic Atrophic Gastritis

Xian Ai-lan

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Abstract

Objective To study the variation of PCNA and Bcl-2 in patients with CAG and CSG.Methods Immunohistochemistry method was used to detect the expression of PCNA and Bcl-2 in normal control group(n=16),chronic superficial gastritis group(n=12),chronic atrophic gastritis(n=44),gastric cancer(n=25).Results The positive rates of PCNA and Bcl-2 were increased.They were found marked difference(P0.01).Conclusion The increase of PCNA and Bcl-2 in CSG and CAG may play important role in promoting carcinogenesis by affecting cell proliferation.

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Objective To study the variation of PCNA and Bcl-2 in patients with CAG and CSG.Methods Immunohistochemistry method was used to detect the expression of PCNA and Bcl-2 in normal control group(n=16),chronic superficial gastritis group(n=12),chronic atrophic gastritis(n=44),gastric cancer(n=25).Results The positive rates of PCNA and Bcl-2 were increased.They were found marked difference(P0.01).Conclusion The increase of PCNA and Bcl-2 in CSG and CAG may play important role in promoting carcinogenesis by affecting cell proliferation.

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Available abstract

Objective To study the variation of PCNA and Bcl-2 in patients with CAG and CSG.Methods Immunohistochemistry method was used to detect the expression of PCNA and Bcl-2 in normal control group(n=16),chronic superficial gastritis group(n=12),chronic atrophic gastritis(n=44),gastric cancer(n=25).Results The positive rates of PCNA and Bcl-2 were increased.They were found marked difference(P0.01).Conclusion The increase of PCNA and Bcl-2 in CSG and CAG may play important role in promoting carcinogenesis by affecting cell proliferation.

Key concepts: Proliferating cell nuclear antigen, Atrophic gastritis, Immunohistochemistry, Carcinogenesis, Medicine, Gastritis, Chronic gastritis, Gastroenterology

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