ScholarLens Back to search
2008•Chinese Journal of Birth Health & HeredityRequires access

Detection of SRY and SOX9 gene on the patients with sex reversal

Yongqian Wang

Open publisher page 0 citations

Abstract

Objective:To investigate the relationship between sex reversal and SRY,SOX9 gene.Methods:Cytogenetic analysis and polymerase chain reaction(PCR) of SRY and SOX9 were performed on the four patients with XX male sex reversal and one with XY female sex reserval.Results:Among the five cases,the positive band of SRY was detected in the three patients with XX male sex reversal and one with XY female sex reversal.The detection of SRY was negative in the other patient with XX male sex reversal.All the five cases have positive band of SOX9.Conclusion:The translocation of SRY gene is one of the important reasons of sex reversal.The abnormality of SOX9 might result in some kinds of sex reversal and its dose-effect need to be studied.

About this research paper

What this paper is about

Objective:To investigate the relationship between sex reversal and SRY,SOX9 gene.Methods:Cytogenetic analysis and polymerase chain reaction(PCR) of SRY and SOX9 were performed on the four patients with XX male sex reversal and one with XY female sex reserval.Results:Among the five cases,the positive band of SRY was detected in the three patients with XX male sex reversal and one with XY female sex reversal.The detection of SRY was negative in the other patient with XX male sex reversal.All the five cases have positive band of SOX9.Conclusion:The translocation of SRY gene is one of the important reasons of sex reversal.The abnormality of SOX9 might result in some kinds of sex reversal and its dose-effect need to be studied.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the relationship between sex reversal and SRY,SOX9 gene.Methods:Cytogenetic analysis and polymerase chain reaction(PCR) of SRY and SOX9 were performed on the four patients with XX male sex reversal and one with XY female sex reserval.Results:Among the five cases,the positive band of SRY was detected in the three patients with XX male sex reversal and one with XY female sex reversal.The detection of SRY was negative in the other patient with XX male sex reversal.All the five cases have positive band of SOX9.Conclusion:The translocation of SRY gene is one of the important reasons of sex reversal.The abnormality of SOX9 might result in some kinds of sex reversal and its dose-effect need to be studied.

Key concepts: Testis determining factor, Sex reversal, SOX9, Y chromosome, Biology, Internal medicine, Medicine, Gene

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Detection of SRY and SOX9 gene on the patients with sex reversal — Research Paper | ScholarLens