Clinical significance of detecting serum human epididymis secretory protein 4 in the diagnosis and prognosis of endometrial cancer

Objective To evaluate the value of detecting serum human epididymis secretory protein 4(HE4) and CA125 in early stage and different pathologic subtypes of endometrial cancer.Methods HE4 and CA125 serum levels of endometrial cancer patients(n=62) and normal people(n=66) were assayed double blindly by ELISA and chemiluminescence methods.The results were analyzed to evaluated the efficiency of two methods in diagnosing endometrial cancer.Results HE4 serum levels of endometrial cancer patients were hingher than that of normal people(209.8±27.3 pmol/L vs.95.0±14.6 pmol/L,P0.05),while CA125 of two groups were similar(39.2±9.4 U/L vs.29.1±8.5 U/L,P0.05).The optimal critical point of HE4 was determined to be 141.5pmol/L based on the ROC curve,and CA125 was 54.5U/L.The statistical difference was distinct of HE4 level between the early stage patients and normal people(157.1±23.4 pmol/L vs.95.0±14.6 pmol/L,P0.05),while there was no difference of CA125 in these two groups(29.9±12.1 U/L vs.29.1±8.5 U/L,P0.05).There was significant statistical difference between stageⅠand Ⅲ both HE4 and CA125(P0.0167),and no difference between stageⅠand Ⅱ.There was statistical difference of HE4 between the stage Ⅱ and Ⅲ(P0.0167),but CA125 was not.The sensitivity of HE4 for diagnosing papillary serous endometrial cancer was higher than that of endometrioid adenocarcinoma(89.4% vs.45.1%,P0.05)when specificity was set as 95%.Conclusion HE4 has been proved high sensitivity among early endometrial cancer,and higher authority in diagnosing papillary serous endometrial cancer than that of endometrioid adenocarcinoma.