An analysis of high dose rate afterloading plus external irradiation in treatment of 105 patients with carcinoma of cervix

? Objective To analyze the validity of iridium 192 high dose rate (HDR) afterloading plus external irradiation in treatment of the carcinoma of cervix and its complications.Methods 105 cases of carcimoma of cervix were treated prospectively.The whole external irradiation dose on pelvic was 25 Gy to 30 Gy for 3 weeks first.The intracavitary afterloading irradiation dose was 5 Gy to 7 Gy once a week at point A,total dosage being 30 Gy to 35 Gy,while the dose of external irradiation on pelvic focusing on cervix was 15 Gy to 20 Gy in one and half to two weeks using four irradiation fields.Results Short term validity (complete response and partial response) wos 100%.The overall 3 years survival rate of the whole series was 83.8% (89.5% for stage Ⅱ and 80.4% for stage Ⅲ).Conclusions The therapeutic method has been confirmed to be relatively effective.Compared with the conventional method, the frequencies of postradiation cystitis and retained rectitis are similiar but that of postradiation vaginal injury is higher.It is important to keep vaginal clean during and after the treatment. 〔