Nuclear Factor-kappa B(NF-κB ) and Associated Molecules with Inflammatory Diseases

In un-stimulated cells, transcription factor NF-κB is kept in cytoplasm through interaction with IκB inhibitory proteins. Exposure to inducers stimuli results in IκB phosphorylation and ubiquitilation. Liberated NF-κB is trans-located to the nucleus and bind to DNA, where they regulate the expression of a wide variety of genes. Recent studies have indicated that the NF-κB plays a central role in the regulation of inflammatory diseases and the study of the regulation of NF-κB pathways will provide a platform for developing specific therapy for inflammatory diseases.