The Influence of Propofol Combined with Epidual Anesthesia on Pressor Response to Intravenous Ephedrine

Objective To investigate the effects of propofol combined with epidural anesthesia on pressor response to intravenous ephedrine.Methods Twenty adult patients of ASA gradeⅠ～Ⅱ undergoing selective operation received propofol combined with epidural anesthesia.All patients received ephedrine 0.1mg/kg IV before and after the anesthetic induction,after propofol combined with epidural anesthesia.The changes of HR,SBP,DBP and MBP were monitored.Results Ephedrine increased the heart rate significantly (P0.05) in wake patients.In contrast,there was no increase in heart rate after the ephedrine administration under propofol anesthesia and propofol combined with epidural anesthesia.We also observed that the magnitudes of the pressor responses to ephedrine during propofol anesthesia and propofol combined with epidural anesthesia were significantly greater(P0.05) than during the awake state.However,the pressor response to intravenous ephedrine was not significantly different between propofol anesthesia and propofol combined with epidural anesthesia.Conclusion Propofol anesthesia augment the pressor responses to intravenous ephedrine.Ephedrine is effective to reverse the hypotention induced by propofol combined with epidural anesthesia.