Synthesis of Diethyl Oximinomalonate

Diethyl oximinomalonate was prepared using diethyl malonate, glacial acetic acid and sodium nitrite as raw materials, toluene as solvent. And the structure of compound was characterized by high performance liquid chromatograph, nuclear magnetic resonance spectrum and mass spectrograph. The influencing factors such as ratio of raw materials and reaction temperature on yield were discussed. And a series of experiment showed good repetitiveness and stability of reaction. The purity of final product is 98% with yield up to 96% (in terms of diethyl malonate).