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2012•Acta Universitatis Medicinalis NanjingRequires access

Expression and significance of MMP-2 protein in esophageal squamous cell carcinoma

Liang Chen

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Abstract

Objective:To investigate the expression of MMP-2 protein in esophageal squamous carcinoma and its clinicopathologic significance.Methods:Immunohistochemical method was used to detect the expression of MMP-2 in 106 cases of squamous esophageal cancer tissues and 50 normal subjects.Results:The positive expression rate of MMP-2 in the squamous esophageal cancer tissues was 80.2% and there were significant difference comparing with normal subjects(P 0.05).The positive rate of MMP-2 was significantly correlated with invasion,clinical stage,lymph node metastasis(P 0.05).Conclusion:The expression of MMP-2 in esophageal squamous carcinoma tissues was high,which suggested that it could be of important clinical value to evaluate invasion,metastasis and prognosis of esophageal squamous carcinoma.

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What this paper is about

Objective:To investigate the expression of MMP-2 protein in esophageal squamous carcinoma and its clinicopathologic significance.Methods:Immunohistochemical method was used to detect the expression of MMP-2 in 106 cases of squamous esophageal cancer tissues and 50 normal subjects.Results:The positive expression rate of MMP-2 in the squamous esophageal cancer tissues was 80.2% and there were significant difference comparing with normal subjects(P 0.05).The positive rate of MMP-2 was significantly correlated with invasion,clinical stage,lymph node metastasis(P 0.05).Conclusion:The expression of MMP-2 in esophageal squamous carcinoma tissues was high,which suggested that it could be of important clinical value to evaluate invasion,metastasis and prognosis of esophageal squamous carcinoma.

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Available abstract

Objective:To investigate the expression of MMP-2 protein in esophageal squamous carcinoma and its clinicopathologic significance.Methods:Immunohistochemical method was used to detect the expression of MMP-2 in 106 cases of squamous esophageal cancer tissues and 50 normal subjects.Results:The positive expression rate of MMP-2 in the squamous esophageal cancer tissues was 80.2% and there were significant difference comparing with normal subjects(P 0.05).The positive rate of MMP-2 was significantly correlated with invasion,clinical stage,lymph node metastasis(P 0.05).Conclusion:The expression of MMP-2 in esophageal squamous carcinoma tissues was high,which suggested that it could be of important clinical value to evaluate invasion,metastasis and prognosis of esophageal squamous carcinoma.

Key concepts: Immunohistochemistry, Medicine, Lymph node metastasis, Esophageal cancer, Matrix metalloproteinase, Esophageal squamous cell carcinoma, Stage (stratigraphy), Pathology

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