ScholarLens Back to search
2009•Unpublished venueRequires access

Effect of dexamethasone on pulmonary fi brosis and endothelin-1 in lung tissue of rats

Feng Hua-song

Open publisher page 0 citations

Abstract

Objective To discuss the effect of dexamethasone on changes of endothelin-1(ET-1) in rats with pulmonary fibrosis induced by bleomycin(BLM).Methods Rats were divided into model group,treatment group and control group.Pulmonary fibrosis was induced by endotracheal injection of bleomycin(5mg/kg).Rats in treatment group were given intraperitoneal injection of dexamethasone(1mg/kg) every other day.Rats in control and model groups received saline instead of dexamethasone.On day 28,the rats were executed.ET-1 and hydroxyproline(HYP) levels in lung tissue were measured.Histopathological changes and endothelin-1(ET-1) in rats with pulmonary fibrosis were observed.Results The HYP and ET-1 levels were significantly higher in model group than in control and treatment groups(P0.01).Conclusion ET-1 plays a role in development of pulmonary fibrosis.Dexamethasone has some inhibitory effects on pulmonary fibrosis,possibly by decreasing the ET-1 level.

About this research paper

What this paper is about

Objective To discuss the effect of dexamethasone on changes of endothelin-1(ET-1) in rats with pulmonary fibrosis induced by bleomycin(BLM).Methods Rats were divided into model group,treatment group and control group.Pulmonary fibrosis was induced by endotracheal injection of bleomycin(5mg/kg).Rats in treatment group were given intraperitoneal injection of dexamethasone(1mg/kg) every other day.Rats in control and model groups received saline instead of dexamethasone.On day 28,the rats were executed.ET-1 and hydroxyproline(HYP) levels in lung tissue were measured.Histopathological changes and endothelin-1(ET-1) in rats with pulmonary fibrosis were observed.Results The HYP and ET-1 levels were significantly higher in model group than in control and treatment groups(P0.01).Conclusion ET-1 plays a role in development of pulmonary fibrosis.Dexamethasone has some inhibitory effects on pulmonary fibrosis,possibly by decreasing the ET-1 level.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To discuss the effect of dexamethasone on changes of endothelin-1(ET-1) in rats with pulmonary fibrosis induced by bleomycin(BLM).Methods Rats were divided into model group,treatment group and control group.Pulmonary fibrosis was induced by endotracheal injection of bleomycin(5mg/kg).Rats in treatment group were given intraperitoneal injection of dexamethasone(1mg/kg) every other day.Rats in control and model groups received saline instead of dexamethasone.On day 28,the rats were executed.ET-1 and hydroxyproline(HYP) levels in lung tissue were measured.Histopathological changes and endothelin-1(ET-1) in rats with pulmonary fibrosis were observed.Results The HYP and ET-1 levels were significantly higher in model group than in control and treatment groups(P0.01).Conclusion ET-1 plays a role in development of pulmonary fibrosis.Dexamethasone has some inhibitory effects on pulmonary fibrosis,possibly by decreasing the ET-1 level.

Key concepts: Bleomycin, Dexamethasone, Pulmonary fibrosis, Hydroxyproline, Medicine, Lung, Saline, Intraperitoneal injection

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of dexamethasone on pulmonary fi brosis and endothelin-1 in lung tissue of rats — Research Paper | ScholarLens