The Influence of Micrometastases of Regiondal Lymph Nodes on the Survival of Patients with Non-Small Cell Lung Cancer

Objective: To detect the micrometastases in lymph nodes at pathologically affirmed non-metastasis area of non-small-cell lung cancer(NSCLC) after radical correction,and to study its influence on the prognosis of the disease.Methods: Paraffin-embedded specimens of hilum and mediastinal lymph node of T1-4N0-1M0 in 107 cases of pathologically affirmed NSCLC patients were collected,and the micrometastasis in them was detected with EnVision method.Results: The total positive rate of micrometastasis in patients was 29.9%.The 1-,3-,and 5-year survival rates and median survival time of non-micrometastasis group were significantly higher than those of micrometastasis group(P0.05).Cox regression prognostic analysis showed that KPS scores,and pathological grade CK,and T were independent predictors of overall survival(P0.05).Postoperative radiochemotherapy showed more advantage than surgery only,but no statistical significance was found(P0.05).Conclusions: Micrometastasis is a disadvantageous factor to survival of patients with NSCLC,and intervention of radiotherapy and chemotherapy could extend patient's life.