Changes of Fas/ FasL and Oxyradical System on the Pulmonary Fibrosis Rats

Objective To investigate the expressions of Fas/FasL,which leads to apoptotic cell,and MDA of the pulmonary fibrosis rats.Methods Thirty-tow rats were divided into three groups randomly,Control group contains sixteen,Model group has eight each.It was used to detect the change of cell apoptosis and the expressions of Fas/FasL and MDA in rats with pulmonary fibrosis caused by bleomycin.Results The apoptosis index of lung cells in the pulmonary fibrosis group was higher than that of control group.The expression of Fas / FasL in the pulmonary fibrosis group was higher than that of control group (P0.01).The contents of MDA were increased on the seventh day(P0.01),but decreased on the 28th day(P0.05) .Conclusion The apoptosis index of lung cells and oxyradical were increased in lung tissue of pulmonary fibrosis rats,Fas/ FasL and oxyradical system may play an important role in the development of disease.