2013•Shengming kexueRequires access

tau protein hyperphosphorylation and Alzheimer’s disease

Song Ming

Abstract

Alzheimer's disease(AD) is one kind of neurodegenerative diseases,also the main reason leading to dementia.tau protein is a microtubule-associated protein,and its hyperphosphorylation plays a key role in the pathogenesis of AD.In this review,we made a summary of latest research progresses on the neurotoxicity of tau protein hyperphosphorylation and the relationship between tau protein hyperphosphorylation and AD.

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Key concepts: Hyperphosphorylation, Tau protein, Neurotoxicity, Neuroscience, Dementia, Alzheimer's disease, Disease, Pathogenesis