Studies on the effects of borneol on the pharmacokinetics of rifampicin

In this paper the effects of borneol on the pharmacokinetics of rifampicin were studied. By a cross over design, six rats were given ig rifampicin(RIF) 20 mg/kg with or without previous borneol 20 mg/kg after an overnight fast. The rifampicin in rats plasma was detected by the RP HPLC method and the pharmacokinetic parameters were calculated by 3P87 software. The results demonstrated that t 1/2ka were 18 36 min and 22 70 min , respectively, t 1/2ke were 569 79 min and 435 52 min , respectively. The peak plasma levels were 12 62 μg mL -1 at 94 03 min and 8 70 μg/mL at 102 06 min , respectively. The area under the plasma concentration time curves was 11 630 64 μg min mL -1 and 6 432 80μg·min·mL -1 , respectively. The results showed that the borneol could significantly enhances the absorption of the rifampicin.