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2008•International Journal of Internal MedicineRequires access

Development of research on matrix metalloproteinases-2 and metalloproteinases-9 in leukemia

Jiaju Liu

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Abstract

Matrix metalloproteinase(MMP) is a family of protein enzymes degrading the extracellular matrix.MMP expression correlates with tumor growth,invasion and metastasis closely,and has gradually become a new target of cancer treatment.In recent years,the study of MMP-2,MMP-9 in leukemia has become a hot topic in research.In this article,the structure and function of MMP-2 and MMP-9,the mechanisms of MMP-2 and MMP-9 in leukemic cell invasion and metastasis,as well as their relationship with clinical effectiveness and prognosis in leukemia were discussed.

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What this paper is about

Matrix metalloproteinase(MMP) is a family of protein enzymes degrading the extracellular matrix.MMP expression correlates with tumor growth,invasion and metastasis closely,and has gradually become a new target of cancer treatment.In recent years,the study of MMP-2,MMP-9 in leukemia has become a hot topic in research.In this article,the structure and function of MMP-2 and MMP-9,the mechanisms of MMP-2 and MMP-9 in leukemic cell invasion and metastasis,as well as their relationship with clinical effectiveness and prognosis in leukemia were discussed.

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Available abstract

Matrix metalloproteinase(MMP) is a family of protein enzymes degrading the extracellular matrix.MMP expression correlates with tumor growth,invasion and metastasis closely,and has gradually become a new target of cancer treatment.In recent years,the study of MMP-2,MMP-9 in leukemia has become a hot topic in research.In this article,the structure and function of MMP-2 and MMP-9,the mechanisms of MMP-2 and MMP-9 in leukemic cell invasion and metastasis,as well as their relationship with clinical effectiveness and prognosis in leukemia were discussed.

Key concepts: Matrix metalloproteinase, Metastasis, Extracellular matrix, Leukemia, Cancer research, Cancer, Biology, Medicine

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Development of research on matrix metalloproteinases-2 and metalloproteinases-9 in leukemia — Research Paper | ScholarLens