Study on Acute Toxicity and Cumulative Toxicity of Areca Catechu Solid Beverage

A kind of Areca catechu solid beverage was developed, and its acute toxicity and cumulative toxicity to mice were studied. The LD50 of betel extracts was detected by improved Karber method. The accumulative coefficient was detected by fixed-dose method. Results showed that the oral LD50 of Areca catechu solid beverage to mice was 8 181 mg/kg and its 95% confidence limit was 6 742～9 620 mg/kg. The accumulative coefficient K of Areca catechu solid beverage was 5.8. This indicated that Areca catechu solid beverage is an actual non-toxic material and safe, and there is mild accumulative toxicity to mice.