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[Study on the distribution and location of neuroglobin in human tissues and cells].

Haojie Qin, Lu-shun Zhang, Na Wu, Yadong Guo, Lin Zhang, Mingyuan Li, Peng Guan

Abstract

OBJECTIVE: To explore the distribution and location of neuroglobin (NGB) and its function in human tissues and cells. METHODS: The distribution and localization of NGB in human tissues and cells were examined by immunohistochemical method. RESULTS: NGB-positive cells were mainly distributed in neurons of central nervous system and peripheral nervous system, and some in endocrine tissues and genital system. NGB-immunoreactive product located in the cytoplasm of these cells. CONCLUSION: The expression of NGB in human nervous tissues, some endocrine tissues and genital system suggested that NGB might play an important role in the utilizations of oxygen and physiological functions.

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Key concepts: Neuroglobin, Immunohistochemistry, Nervous system, Biology, Cytoplasm, Endocrine system, Central nervous system, Function (biology)