Level of Serum Erythropoietin and Clinical Analysis in Patients with Hematologic Malignancies

Objective To detect the level of serum erythropoietin in patients with hematologic malignancies(HM) and the response of patients to erythropoietin.Methods Serum erythropoietin levels were detected by ELISA in patients with HM,with non-cancer-related anemia and normal individuals.Hemoglobin(Hb) and reticulocyte were also detected in each group.Results The erythropoietin,hemoglobin and reticulocyte was(2.72±1.50) μg/L,(87.20±11.20) μg/L and(2.60±0.98)% in patients with HM;(1.59±0.69) μg/L,(136.1±11.3) g/L and(1.17±0.35)% in normal controls;(2.78±1.53) μg/L,(90.5±9.60) g/L and(5.46±2.12)% in patients with non-cancer-related anemia,respectively.There was significant difference in the level of erythropoietin,hemoglobin and reticulocyte of patients with HM compared with normal control(P0.01).There was significant difference in the level of erythropoietin and hemoglobin between patients with HM and with non-cancer-related anemia(P0.01).Conclusions The level of erythropoietin of patients with HM was responsively increased but the reactivity of body to the erythropoietin was weakened.The anemia of patients with HM may be related to this result.