2011•PubMedRequires access

[Content of CD4+ CD25+ regulatory T cells in peripheral blood lymphocytes in patients with allergic rhinitis].

Shaoqing Yu, Yingjian Chen, Jie Zhang, Zhiqiang Yan, Ruxin Zhang

Abstract

OBJECTIVE: To investigate the change of CD4- CD25 regulatory T cells (Tregs) of peripheral blood in allergic rhinitis (AR) patients. METHOD: T lymphocytes of twenty AR patients and eight healthy subjects were separated and the flow cytometry was used to measure the percentage of CD4+ CD25+ Treg. RESULT: Compared with control group, the percentage of Treg and CD4- CD25high Tregs of AR patients was decreased significantly (P < 0.05). CONCLUSION: The proportion of CD4+ CD25+ Tregs decreased in AR patients conspicuously, which might be one of the pathogenesis of AR.

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Key concepts: IL-2 receptor, Flow cytometry, Peripheral blood, Pathogenesis, Immunology, Treg cell, Medicine, Peripheral