2009•Chinese Journal of Dermatovenereology of Integrated Traditional and Western MedicineRequires access
Effects of Psoriasis II Docoction on Serum Neopterin in Psoriasis Patients
Qingyan Chen
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Abstract
Objective To investigate the clinical effects of psoriasis Ⅱ docoction on treating blood-heat type psoriasis vulgaris, and to study the role of serum neopterin (Npt) level in measuring the effects of Chinese medicine treatment in psoriasis. Methods 78 patients of blood-heat type psoriasis vulgaris were randomly divided into two groups. 38 cases in treatment group were treated with psorioasis Ⅱ dcoction, and 40 cases in control group were treated with Xiaoyin Keli. Serum Npt level was detected by ELISA, and the relationship between serum Npt level and PASI score of the two groups was analyzed. Results The total effective rate in psorioasis Ⅱ group was higher than Xiaoyin Keli group(86.84% vs. 67.50%, χ2= 4.11, P0.05). There was a significant correlation between pretreatment or posttreatment Npt levels and PASI scores in all patients. After treatment, Npt levels of treated group was lower than those of control group (7.09±2.21nmol/L vs. 11.45±2.17 nmol/L, P0.05). Conclusion Psorioasis Ⅱ docoction shows a satisfactory effect on blood-heat type psoriasis vulgaris, and it can obviously lower the Npt levels. Serum Npt levels can be considered as an useful marker for measuring the effect of Chinese medicine treatment in blood-heat type psoriasis vulgaris.