Association of FTO Gene rs9939609,etc Polymorphisms with Obesity in Kazakh of Xinjiang

Objective:To investigate the association of the fat-mass and obesity-associated(FTO)gene rs1421085,rs8050136,rs9939609polymorphism on overweight and obesity in Kazakh of Xinjiang.Methods:Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry(MALDI-TOF-MS)was used to detect FTO gene rs1421085,rs8050136and rs9939609genotypes in 489subjects(including 252overweight and obesity patients,237controls).Results:1)The frequencies of CC genotype of rs1421085:obesity group was 7.2%,overweight group was 4.4%,and the control group was 5.6%.The frequencies of AA genotype of rs8050136:obesity group was 6.3%,overweight group was 5.8%,and the control group was 5.9%.The frequencies of AA genotype of rs9939609:obesity group was 6.4%,overweight group was 4.3%,and the control group was 5.6%.The frequencies of FTO gene rs1421085,rs8050136and rs9939609genotypes existed significantly difference between overweight,obesity and controls group.2)The frequencies of FTO gene rs1421085,rs8050136and rs9939609genotypes and alleles existed significantly different between overweight+obesity and controls group in Kazakh.3)There existed significant differencein Fasting Plasma Glucose(FPG)between the rs1421085AA+TC genotypes when compared with TT genotypes(P=0.045);However,other relevant indicators showed no significant difference between the CC+CA genotypes and TT genotypes.There was no significant association between rs9939609,rs8050136and obesity-related traits.Conclusion:The polymorphism in FTO gene at rs9939609,rs8050136and rs1421085is not associated with obesity in Kazak population.Difference in FDG between rs1421085TT genotype and AA+TC genotype shows statistic significance.The effects of pdymorphism of the Execpt existed significant other sites on metabolic indicators show no difference.