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2014•Huaxi yaoxue zazhiRequires access

Determination of the dissolution of anti-hypertensive drug Compound Amlodipine and Ramipril tablets

Dai Shi-yin

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Abstract

OBJECTIVE To establish a methodology for the determination of the dissolution of Amlodipine and Ramipril in anti-hypertensive drug Compound Amlodipine and Ramipril tablets. METHODS The dissolution curves were generated by use of paddle( apparatus II) method at 50 r·min-1and water with a volume of 900 mL as dissolvent. HPLC was performed to determine the dissolution of Amlodipine and Ramipril. RESULTS The linearity of the proposed method was investigated in the range of 0. 195-7. 80 μg· mL-1( r2= 0. 9999) for Amlodipine and 0. 151-6. 04 μg·mL-1( r2= 0. 9999) for Ramipril. The average recovery of Amlodipine and Ramipril was 98. 74% and 98. 80%,respectively. CONCLUSION The improved method is simple,accurate and specific. It can be applied for the quality control in anti-hypertensive drug Compound Amlodipine and Ramipril tablets.

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OBJECTIVE To establish a methodology for the determination of the dissolution of Amlodipine and Ramipril in anti-hypertensive drug Compound Amlodipine and Ramipril tablets. METHODS The dissolution curves were generated by use of paddle( apparatus II) method at 50 r·min-1and water with a volume of 900 mL as dissolvent. HPLC was performed to determine the dissolution of Amlodipine and Ramipril. RESULTS The linearity of the proposed method was investigated in the range of 0. 195-7. 80 μg· mL-1( r2= 0. 9999) for Amlodipine and 0. 151-6. 04 μg·mL-1( r2= 0. 9999) for Ramipril. The average recovery of Amlodipine and Ramipril was 98. 74% and 98. 80%,respectively. CONCLUSION The improved method is simple,accurate and specific. It can be applied for the quality control in anti-hypertensive drug Compound Amlodipine and Ramipril tablets.

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Available abstract

OBJECTIVE To establish a methodology for the determination of the dissolution of Amlodipine and Ramipril in anti-hypertensive drug Compound Amlodipine and Ramipril tablets. METHODS The dissolution curves were generated by use of paddle( apparatus II) method at 50 r·min-1and water with a volume of 900 mL as dissolvent. HPLC was performed to determine the dissolution of Amlodipine and Ramipril. RESULTS The linearity of the proposed method was investigated in the range of 0. 195-7. 80 μg· mL-1( r2= 0. 9999) for Amlodipine and 0. 151-6. 04 μg·mL-1( r2= 0. 9999) for Ramipril. The average recovery of Amlodipine and Ramipril was 98. 74% and 98. 80%,respectively. CONCLUSION The improved method is simple,accurate and specific. It can be applied for the quality control in anti-hypertensive drug Compound Amlodipine and Ramipril tablets.

Key concepts: Ramipril, Amlodipine, Chemistry, Dissolution, Chromatography, Pharmacology, Dissolution testing, ACE inhibitor

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