2007•Unpublished venueRequires access

CLINICAL SIGNIFICANCE OF PROMOTER METHYLATION OF P16 GENE IN GASTRIC CANCER

Yongfu Wang

Abstract

Objective:To investigate the clinical significance of promoter methylation of P16 gene in gastric cancer.Methods: The methylation status of P16 on surgically removed tumour tissues were examined by methylation-specific polymerase chain reaction(MSP) in 37 cases with gastric cancer.Results: Among samples obtained from patients with gastric cancer,methylation was observed in both the cancerous and paracancerous tissues with 29.7% and 2.7% for P16 respectively.No significant correlation between methylation status of P16 and clinical pathological characteristic was observed.Conclusion: Methylation of P16 gene is likely to be cancer specific(P0.05),and may be utilized as a molecular diagnostic marker of gastric cancer in its early stage.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Methylation, Cancer, Clinical significance, Cancer research, Pathological, DNA methylation, Gene, Polymerase chain reaction