2000•Unpublished venueRequires access
Pathomorphology of spleen lymphocyte apoptosis in large dose ~(60)Co γ-irradiated mice.
Yang Hong
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Abstract
Objective The aim of this study was to investigate the pathomorphological changes of spleen lymphocyte apoptosis after 60 Co γ-irradiation. Methods The mice were irradiated with 6,9,12,15 and 20 Gy of 60 Co γ-rays. At different times after irradiation,the mice were sacrificed and the pathological changes of spleen lymphocyte were observed by light and transmission electron microscopies. Results Spleen lymphocyte decreased evidently and the peak of apoptosis in spleen lymphocyte was dependent on radiation dose and the time after irradiation. Conclusion After γ-irradiation with large doses,pathological changes of spleen lymphocyte apoptosis in mice can be divided into obviously different stages. The main causes of death of spleen lymphocytes are different in different dose groups.