2006•PubMedRequires access

[Optimization of formulation of Fufang Danshen immediate release tablet by colligation score].

Rongfeng Hu, Jia-bi Zhu, Daiyin Peng, Jihui Tang, An Zhou

Abstract

OBJECTIVE: To optimize the formulation of immediate release tablet. METHOD: The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices. RESULT: The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively. CONCLUSION: It is successful to prepare on immediate release tablet using the optimized formula above.

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Key concepts: Microcrystalline cellulose, Dextrin, Carboxymethyl cellulose, Chromatography, Materials science, Dissolution, Chemistry, Mathematics