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GLYCOCALYX AND MECHANOTRANSDUCTION

Deng Xiaoyan, Hongyan Kang

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Abstract

Glycocalyx on the surface of vascular endothelial cells is of a hair-like structure composed of various proteoglycans and glycoproteins and is a barrier with selective permeability for the vascular wall.It has been known that glycocalyx can assist red blood cells in their motion through capillaries,prevent the adhesion of blood cells and participate in signal communications.It has been well documented that glycocalyx may also take part in shear stress sensing and transduction.This article briefly reviews the physiological functions of glycocalyx with particular emphases on its roles in mechanotransduction.

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What this paper is about

Glycocalyx on the surface of vascular endothelial cells is of a hair-like structure composed of various proteoglycans and glycoproteins and is a barrier with selective permeability for the vascular wall.It has been known that glycocalyx can assist red blood cells in their motion through capillaries,prevent the adhesion of blood cells and participate in signal communications.It has been well documented that glycocalyx may also take part in shear stress sensing and transduction.This article briefly reviews the physiological functions of glycocalyx with particular emphases on its roles in mechanotransduction.

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Available abstract

Glycocalyx on the surface of vascular endothelial cells is of a hair-like structure composed of various proteoglycans and glycoproteins and is a barrier with selective permeability for the vascular wall.It has been known that glycocalyx can assist red blood cells in their motion through capillaries,prevent the adhesion of blood cells and participate in signal communications.It has been well documented that glycocalyx may also take part in shear stress sensing and transduction.This article briefly reviews the physiological functions of glycocalyx with particular emphases on its roles in mechanotransduction.

Key concepts: Glycocalyx, Mechanotransduction, Cell biology, Adhesion, Vascular permeability, Glycobiology, Glycoprotein, Biophysics

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