Ulinastatin and Aprotinin to Blood Protection of Operation on Vessels of Heart

Objective To observe the ulinastatin and aprotinin to blood protection of extracorporeal circulation heart operation.Methods To select 90 cases of rheumatic heart disease undergoing valve replacement,90 patients were divided into three groups.The ulinastatin group(n=30):supply ulinastatin 12 000 IU/kg,after anesthesia induction to the begin of CPB,slow intravenous injection with half dose,the other half added to the priming solution and transfered into the body; the aprotinin group(n=30):In the CPB,supply the 5 million units aprotinin of one-time; the control group(30 cases):supply normal saline.Results Compared with the control group,there were significant decrease in 24-hours chest tube drainage in ulinastatin group(33.3% reduction),and 39.8% reduction in 24-hours chest tube drainage in aprotinin group(P0.05).Ulinastatin group and aprotinin group had no significant difference.Aprotinin group had two cases of severe allergy.Conclusion Ulinastatin and aprotinin had effect in stabilizing fibrinolytic system,preserving platelet function during,leading to less postoperative blood loss.