Compare anesthesia maintained by propofol target-controlled infusion with by propofol combined with midazolam in laparoscopic cholecystectomy.

Objective To study the qualitative of general anesthesia maintained by propofol target-controlled infusion(TCI)or by propofol combined with midazolam in laparoscopic cholecystectomy(LC).Methods Sixty patients scheduled for LC were randomized to two groups:TCI group(A-group,n=30),propofol combined with midazolam(B-group,n=30).The patients in A-group were given TCI with the target concentration 4μg/ml during induction and 3～3.5μg/ml during maintenance.And in B-group were accepted 0.1mg/kg midazolam,1mg/kg propofol during induction and infused 10-8-6mg/kg.h propofol during maintenance.SBP,DBP and HR were monitored continuously during operation.The time of anesthesia and extubation,the qualitative and the representation(agitation,nausea,vomit)of recovery were recorede in operation.Results The vital sings of patients in two groups after 3-min induction were lower than those before induction(P0.05).The vital sings of patients in two groups after 10-min aeroperitonia were higher than those before induction,after 3-min induction and intubation(P0.05).But there have no difference between two groups.The time of extubation in A-group was shorter than B-group(P0.05).The qualitative of consciousness of A-group was better than B-group(P0.05).Conclusion The anesthesia maintenance by propofol TCI in LC is better than midazolam combined with propofol.