Effects of sufentanil combined with target controlled infusion of propofol on hemodynamics in geriattrics with laparoscopic cholecystectomy during anesthesia indpcfion

Objective To evaluate the effects of different doses of sufentanil combined with target controlled infuJsion(TCI) of propofol on hemodynamics in geriatrics with laparoscopic cholecystectomy druing anesthesia induction and the appropriate dose of sufentanil.Methods One hundred geriatrics were randomly allocated into four groups:S1、S2、S3、S4,there were 25 cases in every group.Anesthesia was induced with iv injection of midazolam 0.03mg/kg,TCI of propofol(target plasma concentration set at 2.0μg/ml)and iv injection of sufentanil 0.5、0.6、0.7、0.8μg/kg.Tmcheal intubation was faCiliated with vecuronim0.1mg/kg.SP,DP,MAP and HR were assessed before induction of anesthesia(T0),at the time of propofol achieving the targetplasma concentration of 2.0μg/ml(T1),at 1min(T2)after iv injection of sufentanil,before tracheal intubation(T3),and immediately(T4)and at 1min(T5),3min(T6) and 5min(T7)after tracheal intubation.Results The EC50 of propofol and 95% confidence interval were 2.05(1.98～2.21)、1.97(1.88～2.16)、1.65(1.52～1.85)and 1.58(1.45～1.68)μg/ml respectively in group S1、S2、S3 and S4.EC50 was significantly lower in group S3 and S4 than in group S1 and S2(P0.05).The incidence of hypotension at T1～3 and T4 was significantly higher in group S3 and S4 than in group S1 and S2(P0.05).The incidence of bradycardia at T5～7 was significantly higher in group S3 and S4 than in groupS1 and S2(P0.05).Ther ewere no significant in the incidence of hypertension and tachycardia at T4 between four groups(P0.05).Conclusion Sufentanil 0.5~0.6μg/kg is the dose of choice for anesthesia induction when combined with propofol TCl(target plasma concentration set at 2.0μg/ml) in geriatrics laparoscopic cholecystectomy and hemodynamics is stable.