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2007•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Effect of bone marrow-derived mesenchymal stem cells on collagen of injured rat lung

Xinyu Ti

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Abstract

Objective:To investigate the effect of bone marrow-derived mesenchymal stem cells(MSCs) on collagen of injured rat lung induced by bleomycin and its mechanism.Methods: MSCs,isolated from SD rats,were injected into recipient rats.Two weeks later, lung tissues were collected and lung structure,collagenⅠ,Ⅲ and hydroxyproline were detected.The expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA were also examined.Results: The thickness of alveolar wall,collagenⅠ,Ⅲ and hydroxyproline in lung tissue in MSCs treatment group were reduced significantly than those in lung injury group.MSCs engraftment can also reduce the expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA in injured lung.Conclusion:MSCs could reduce the collagen in injured lung and this effect may be associated with the decrease of TGF-β1,PDGF-A,PDGF-B and IGF-Ⅰ expressions induced by MSCs engraftment.

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What this paper is about

Objective:To investigate the effect of bone marrow-derived mesenchymal stem cells(MSCs) on collagen of injured rat lung induced by bleomycin and its mechanism.Methods: MSCs,isolated from SD rats,were injected into recipient rats.Two weeks later, lung tissues were collected and lung structure,collagenⅠ,Ⅲ and hydroxyproline were detected.The expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA were also examined.Results: The thickness of alveolar wall,collagenⅠ,Ⅲ and hydroxyproline in lung tissue in MSCs treatment group were reduced significantly than those in lung injury group.MSCs engraftment can also reduce the expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA in injured lung.Conclusion:MSCs could reduce the collagen in injured lung and this effect may be associated with the decrease of TGF-β1,PDGF-A,PDGF-B and IGF-Ⅰ expressions induced by MSCs engraftment.

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Available abstract

Objective:To investigate the effect of bone marrow-derived mesenchymal stem cells(MSCs) on collagen of injured rat lung induced by bleomycin and its mechanism.Methods: MSCs,isolated from SD rats,were injected into recipient rats.Two weeks later, lung tissues were collected and lung structure,collagenⅠ,Ⅲ and hydroxyproline were detected.The expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA were also examined.Results: The thickness of alveolar wall,collagenⅠ,Ⅲ and hydroxyproline in lung tissue in MSCs treatment group were reduced significantly than those in lung injury group.MSCs engraftment can also reduce the expression of TGFβ1,PDGF-A,PDGF-B and IGF-ⅠmRNA in injured lung.Conclusion:MSCs could reduce the collagen in injured lung and this effect may be associated with the decrease of TGF-β1,PDGF-A,PDGF-B and IGF-Ⅰ expressions induced by MSCs engraftment.

Key concepts: Mesenchymal stem cell, Hydroxyproline, Lung, Platelet-derived growth factor receptor, Bone marrow, Medicine, Pathology, Bleomycin

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