2002•Tianjin Yike Daxue xuebaoRequires access
The changes and clinical significance of levels of IL-6 and TNF-α in patients with acute leukemia
Zhi Yao
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Abstract
Objective:To evaluate the changes in levels of IL-6 and TNF-α in patients with acute leukemia before and after chemotherapy.Methods: The levels of IL-6 and TNF-α before and after chemotherapy in 30 patients with acute leukemia were detected with bioactivity assessment method.Results:The levels of IL-6 activity in patients with acute leukemia before chemotherapy were significantly higher than that of normal control group(P0.05),and after chemotherapy the levels of IL-6 in patients were much lower than that of normal control group(P0.05),also distinctly lower than those before chemotherapy(P0.05).The levels of TNF-α activity in patients with acute leukemia were significantly lower than that of normal control group(P0.05),after chemotherapy they were distinctly higher than those before chemotherapy(P0.05), also higher than that of normal control group(P0.05).Conclusion: Both IL-6 and TNF-α take part in the process of acute leukemia.