THE HIGH-RISK FACTORS OF BRONCHOPULMONARY DYSPLASIA AMONG VERY LOW BIRTH WEIGHT INFANT

[Objective]To analyze the high-risk factors of bronchopulmonary dysplasia among very low birth weight infant(VLBWI).[Methods]The cases of 69 VLBWI whose birth weight≤1 500 g,age≤36 weeks and survival time ≥28 days admitted to neonatal intensive care unit in our hospital in the last 6 years were analyzed retrospectively.Compared gestational age,birth weight,neonatal respiratory distress syndrome,mechanical ventilation time,24-48 h liquid intake after birth and repeated lung infection among 27 cases of BPD(BPD group)and 42 patients with non-BPD(control group)VLBWI.[Results]Univariate analysis showed that young gestational age,low birth weight,mechanical ventilation≥10d,and repeated lung infections were independent risk factors for BPD incidence(P﹤0.05);Multivariate Logistic regression showed that gestational age was the high risk factor for VLBWI suffering from BPD(OR = 0.656,P = 0.031).[Conclusion]Avoiding prolonged mechanical ventilation of the very low birth weight and/or premature birth infants and effectively controlling pulmonary infection are the keys for BPD prevention and treatment.