Raw Rhubarb Nasal Jejunal Tube Perfusion Applicaition Value in Acute Pancreatitis

Objective: To evaluate the feasibility and effectiveness of the raw rhubarb nasal jejunal tube perfusion application of the acute pancreatitis. Methods: In our hospital from January 2011 to June 2013,107 cases of patients with acute pancreatitis were selected as the research object,including 32 cases of severe acute pancreatitis. By digital method,they were randomly divided into observation group( 55 cases) and control group( 52 cases). Observation group used nasal jejunal tube perfusion and the control group used the stomach tube injection amount of isothermal raw rhubarb fluid. We compared two groups' APACHE Ⅱ score,Balthazar CT integral,jejunum arrival rate and adverse reaction rate,success rate as well as c- reactive protein,blood amylase,anus exhaust defecation function,stomach ache elimination and bowel sound recovery time and observed the two groups' IL- 6 and IL- 1 bacterial endotoxin levels after treatment. Results:The observation group's APACHE Ⅱ score was( 4. 48 ± 1. 44),significantly lower than that of the control group( 5. 32± 1. 04) and the difference was statistically significant( P 0. 05). The observation group's Balthazar CT( 2. 57 ±1. 38) points compared with control group's( 2. 98 + 1. 15) points had no statistically significant difference( P 0. 05).12 h jejunum arrival rate in observation group was 74. 55% and the success rate was 96. 36%,significantly higher than those of control group 50. 00%,84. 62% and both had statistically significant differences( all P 0. 05). Observation group's adverse reaction rate was 5. 45%,significantly less than 21. 15% of the control group and the difference was statistically significant( P 0. 05). No obvious difference was found between two groups of 24 h jejunum arrival rate( P 0. 05). Observation group's blood c- reactive protein,amylase,anus exhaust defecation function,stomach ache elimination and bowel sounds recovery time were significantly higher than those of control group and the differences were statistically significant( all P 0. 05). Observation group's serum IL- 1,IL- 6 and bacterial endotoxin level were respectively( 28.75 ±7.32) pg/mL,( 33.56 ±8.12) pg/mL and pg/mL( 21.03 ±13.66),significantly lower than( 34.77 ±7.70)pg /mL,( 38. 35 ± 6. 45) pg /mL,( 33. 25 ± 10. 14) pg /mL in the control group and the differences were statistically significant( P 0. 05). Conclusion: Raw rhubarb nasal jejunal tube perfusion technique for the treatment of patients with acute pancreatitis can effectively improve the cure rate,reduce the stimulation of the pancreas,shorten the recovery time of gastrointestinal function and reduce the complications of adverse reactions. It is worthy of promotion.