Change and Clinical Significance of Serum IL-6,IL-10,and IL-17 level in Children with Hand,Foot,and Mouth Disease

【Objective】 To study the changes and clinical significance of serum interleukin(IL)-6,IL-10,and IL-17 levels in the children with hand foot and mouth disease(HFMD).【Method】 The serum concentration of IL-6,IL-10,and IL-17 in 19 cases of HFMD children(acute stage and convalescence) and 20 cases of healthy controls were measured by ELISA.The cytokines levels were compared.【Results】 1.Compared with healthy controls,the levels of IL-6,IL-10,and IL-17 in acute stage of HFMD were significantly increased in HFMD children(P 0.01).There was no significant difference of the levels of IL-6 and IL-17 between the convalescence of HFMD and healthy children(P 0.05),However the levels of IL-10 in convalescence of HFMD were higher than healthy children(P 0.01).2.Spearman correlation analysis revealed that IL-6 and IL-17 were negatively correlated with IL-10(P 0.05);IL-6 positively correlated with and IL-17 in acute stage(P 0.01).In convalescence IL-6 was negatively correlated with IL-10(P 0.05),positively correlated with IL-17(P 0.01);IL-10 and IL-17 have no correlative relation(P 0.05).【Conclusions】 1.The levels of IL-6 and IL-17 were significantly increased in acute stage of HFMD children.2.The persistent elevation of serum IL-10 level was found in HFMD patients after convalescence.