The Relationship Between Galectin-3 and Smad4 and Invasiveness and Metastasis in Colon Carcinoma

Objective To study the expression of Galectin-3 and Smad4 in colon cancerous tissues and corresponding adjacent tissues and the relationship between Galectin-3 and Smad4 expression and biological behavior in colon carcinoma.Methods Immunohistochemistry method of S-P was used to examine Galectin-3 and Smad4 expression in 61 primary colon cancerous tissues and corresponding adja-cent tissues.Results Positive Galectin-3 expression was observed in 82% of the colon cancer cases but in 26.2% of the adjacent tissues.Positive Smad4 expression was observed in 24.6% the colon cancer cases but in 80.3% of the adjacent tissues.Overexpression of Galectin-3 and expression absence of Smad4 correlated with adifferentiation invasiveness and metastsis in colon carcinoma.Conclusion A significantly stronger expression of Galectin-3 in cancerous tissues is observed.A significant correlation is observed between upregulation of Galectin-3 and downregulation of Smad4 and differentiation,depth of tumor invasion stage and metastases.The both might be a useful tumor marker for colon carcinomas with respects to tumor metastasis,proliferation.