Investigation of the relation between serum hepatitis B virus large protein and HBV DNA levels in patients with hepatitis B virus

Objective To investigate the relation between serum hepatitis B virus large protein(HBV-LP) and HBV DNA levels in patients with hepatitis B virus and approach the dependability between the parameters and their clinical significance. Methods Serum HBV DNA level was quantitatively detected using real-time polymerase chain reaction,HBV-LP and HBV markers expression were measured by enzyme-linked immunosorbent assay (ELISA) in 238 infected sera. Results There was significant difference between the levels of HBV DNA and HBV-LP (P 0.05). The expressions of HBV DNA and HBV-LP were significantly different among various patterns of HBV serological markers (P 0.05). HBV-LP expression was markedly correlated with the logarithm of HBV DNA level (r = 0.677,P 0.001). Conclusion There is a prefect correlation between the copies of HBV DNA and the level of HBV-LP in serum,but HBV-LP expression still can not reflect the replication of HBV.